Mitochondrial respiration modulates Hsf1 activation and the heat shock response.
Donovan W. McDonald, Annisa Dea, Rares Sava, Young Joon Kim, Laura Joos, David Pincus, Martin L. Duennwald
This study shows that mitochondrial respiration impairs Hsf1 activation and the heat shock response in yeast, with alternative chaperone programming compensating for reduced proteostasis.
bioRxiv · May 11, 2026 · PreprintMolecular Biology