Martin L. Duennwald

Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity

This study shows CBD protects neurons from 6-OHDA toxicity by preserving Nrf2 function and mitochondrial integrity through antioxidant mechanisms.

TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70

This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.

Mitochondrial respiration modulates Hsf1 activation and the heat shock response.

This study shows that mitochondrial respiration impairs Hsf1 activation and the heat shock response in yeast, with alternative chaperone programming compensating for reduced proteostasis.

STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers

This study identifies how STIP1/HOP interacts with a-Syn to promote toxic oligomer formation in synucleinopathies.

Deciphering the circular RNAs landscape in amyotrophic lateral sclerosis

This study identifies circRNAs involved in ALS and related motor neuron diseases, showing their regulatory roles through miRNA sponging and interactions with RNA-binding proteins.

Adjusting extracellular pH restores proteostasis and extends lifespan in a yeast model of polyglutamine toxicity

The paper shows that adjusting extracellular pH to prevent acidification extends yeast lifespan by enhancing the heat shock response and promoting polyQ aggregation.

A yeast model of the ALS protein Matrin3 uncovers Hsp90 and its co-chaperone Sti1 as modifiers of misfolding and toxicity

The paper establishes a yeast model of Matrin3, showing it forms inclusions and is toxic, and identifies Hsp90 and Sti1 as modifiers of its misfolding and toxicity.

Sfp1 regulates the SAGA component Tra1 in response to proteotoxic stress in Saccharomyces cerevisiae

The paper shows that Sfp1 regulates Tra1 expression in response to polyQ protein stress in yeast, linking TORC1 to SAGA complex function.