Age and neuroinflammation are important components of the mechanism of cognitive and neurobehavioral deficits in sickle cell disease.
Raven A. Hardy, Noor Abi Rached, Jayre A. Jones, David R. Archer, Hyacinth I. Hyacinth
This study shows that aging, neuroinflammation, and reduced neuroplasticity contribute to cognitive and neurobehavioral deficits in sickle cell disease, with potential therapeutic benefits from minocycline treatment.
bioRxiv · Mar 24, 2020 · PreprintNeuroscience