Hyacinth I. Hyacinth

This study shows that neuroinflammation and lipid dysregulation contribute to social stress-induced cognitive deficits in sickle cell disease using a mouse model.

This paper develops a genomic risk score for intracerebral hemorrhage using genome-wide association data and validates its predictive power in multiple cohorts.

This study shows that aging, neuroinflammation, and reduced neuroplasticity contribute to cognitive and neurobehavioral deficits in sickle cell disease, with potential therapeutic benefits from minocycline treatment.

This study shows that aged SCD mice develop cerebral vasculopathy features seen in humans, with increased RBC velocity, occlusive events, and microinfarcts detected via in vivo two-photon imaging.