Nucleic acid strand length governs mitochondrial reprogramming and mtROS-associated antiviral responses following TLR3 engagement
Duale Ahmed, Malak Al Daraawi, Allan Humphrey, Omar Abdo, David Roy, Mary-Elizabeth Sheridan, Zoya Versey, Rayhane Mejlaoui, Allison F. Jaworski, Alex Edwards, Alfonso B. Abizaid, Ashok Kumar, Ashkan Golshani, Edana Cassol
This study shows that mitochondrial reprogramming and mtROS production differ based on the length of nucleic acid ligands engaged by TLR3, affecting antiviral responses in macrophages.
bioRxiv · Dec 5, 2025 · PreprintImmunology