Single cell in vivo analysis of type I IFN and NK cell-mediated control of B cell infection densities during acute gammaherpesvirus infection
Razieh Zargari, Viktoria Rex, Gang Li, James Craig Forrest, Reinhold Förster, Korbinian Brand, Melanie M. Brinkmann, Stephan Halle
This study uses in vivo single-cell analysis to show that type I IFN signaling and NK cells limit MHV68 infection in lymph nodes, with IFNAR deficiency increasing infected B cell numbers and NK cell depletion enhancing viral spread.
bioRxiv · Jun 16, 2026 · PreprintImmunology