Stephan Halle

Single cell in vivo analysis of type I IFN and NK cell-mediated control of B cell infection densities during acute gammaherpesvirus infection

This study uses in vivo single-cell analysis to show that type I IFN signaling and NK cells limit MHV68 infection in lymph nodes, with IFNAR deficiency increasing infected B cell numbers and NK cell depletion enhancing viral spread.

Protective function of ex vivo expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression

Herpes Simplex Virus Assembly and Spread in murine skin after infection from the outside

This paper develops a novel murine ex vivo skin explant model to study HSV-1 infection and spread in intact skin, showing HSV-1 exclusively spreads in the epidermis through infected keratinocytes.

Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments

The paper develops an agent-based model to evaluate CTL killing mechanisms using 2-photon imaging data, finding that increased contact frequency with infected cells raises killing probability, independent of signal integration.