Gang Li

Three-hinge gyri link individualized folding topology to cortical and superficial white-matter diffusion organization

The paper links individualized cortical folding topology to diffusion properties in cortical and superficial white matter using diffusion MRI data.

Grow2Fold: mapping heterogeneous developmental growth to human brain folding

Grow2Fold models brain folding by integrating imaging data with mechanical simulations to show differential growth drives cortical folding patterns.

Class-wide sequence, structural, and docking-profile diversity of insect odorant receptors and structural specialization of Orco

The paper analyzes insect odorant receptor (OR) diversity across 115 species using sequence, structure, and docking profiles, finding associations with diet and habitat and identifying a conserved Orco domain.

Division-Specific Organization of a Shared Functional Scaffold in the Early-Life Human Brain

This paper develops a fine-grained whole-brain functional parcellation framework for early human development and identifies a shared functional scaffold with division-specific organization.

Cross-attention and language models reveal the interpretability of functional predictions for the human olfactory receptor family

This study introduces CrossVOI, a framework for VOC-OR interaction prediction using protein language models and cross-attention, showing improved performance and interpretability of attention mechanisms in human olfactory receptors.

Transfer learning reveals species-specific olfactory preferences in Diptera and informs pest management strategies

This study develops a transfer learning model to predict volatile-odorant receptor interactions in Diptera, revealing species-specific olfactory preferences and informing pest management strategies.

Single cell in vivo analysis of type I IFN and NK cell-mediated control of B cell infection densities during acute gammaherpesvirus infection

This study uses in vivo single-cell analysis to show that type I IFN signaling and NK cells limit MHV68 infection in lymph nodes, with IFNAR deficiency increasing infected B cell numbers and NK cell depletion enhancing viral spread.

Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment

This study shows that selenoprotein P deficiency promotes hepatocellular carcinoma by inducing neutrophil senescence and an immunosuppressive microenvironment.

Super-resolution single-cell spatial atlas of plant de novo regeneration

The paper constructs a super-resolution single-cell spatial atlas of tomato de novo regeneration using multimodal spatial transcriptomics.

Cell-type specific inference from bulk RNA-sequencing data by integrating single cell reference profiles via EPIC-unmix

EPIC-unmix improves cell-type specific analysis from bulk RNA-seq by integrating single-cell reference profiles, identifying novel genes and eQTLs in Alzheimer's disease.

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.