Guanine content in the CTCF motif encodes a vulnerability to persistent, alcohol-induced redistribution
Ben Nolan, Joynob Akter Puspo, Iesha M Querry-Peterson, Stephanie Maurina, Rebecca A Wright, Allyson Schmitz, Lauren E Jacobsen, Coralmarie Ortiz, Timothy E. Reznicek, Alexander Ethell, Hannah L. Harris, Christopher T. Cummings, M. Jordan Rowley
The paper shows alcohol exposure disrupts chromatin by altering CTCF and cohesin occupancy at guanine-rich sites, leading to lasting gene expression changes.
bioRxiv · Oct 16, 2026 · PreprintMolecular Biology