Hannah L. Harris

The paper shows alcohol exposure disrupts chromatin by altering CTCF and cohesin occupancy at guanine-rich sites, leading to lasting gene expression changes.

The paper introduces CRUSH, a method to refine chromatin compartments to 1 kb resolution, revealing regulatory programs across cell types and a woolly mammoth's cold-adapted regulome.

HiCrayon co-visualizes 3D chromatin conformation with 1D genomic data to reveal new insights into chromatin organization.

This paper introduces a deep learning model to predict A/B compartments from histone modifications, achieving high accuracy across cell types and showing the importance of specific histone marks.

The paper uses ultra-deep Hi-C and a new computational method to fine-map nuclear compartments, revealing that active promoters and enhancers localize in the A compartment even when adjacent sequences are inactive.

The paper shows that the inactive X chromosome modulates the expression of the active X chromosome in humans, affecting 38% of X-linked genes and contributing to sex differences in disease.