M. Jordan Rowley

Guanine content in the CTCF motif encodes a vulnerability to persistent, alcohol-induced redistribution

The paper shows alcohol exposure disrupts chromatin by altering CTCF and cohesin occupancy at guanine-rich sites, leading to lasting gene expression changes.

A novel RNA-binding activity of ECD contributes to U5 snRNP stability and pre-mRNA splicing

This study identifies ECD's RNA-binding activity and shows it stabilizes U5 snRNP and is essential for pre-mRNA splicing.

Kilobase-scale compartments enabled by CRUSH reveal regulatory programs across cell types, single-cells, and ancient mammoths

The paper introduces CRUSH, a method to refine chromatin compartments to 1 kb resolution, revealing regulatory programs across cell types and a woolly mammoth's cold-adapted regulome.

The Splicing Factor PTBP1 interacts with RUNX1 and is Required for Leukemia Cell Survival

The paper identifies PTBP1 as a RUNX1 interacting partner required for leukemia cell survival through metabolic gene regulation.

ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis

This study identifies ECD as a novel androgen receptor target that promotes prostate cancer by enhancing glycolysis and oncogenic traits.

ECD co-operates with ERBB2 to promote tumorigenesis through upregulation of unfolded protein response and glycolysis

This study shows ECD and ERBB2 cooperate in breast cancer by enhancing unfolded protein response and glycolysis through direct mRNA binding and increased glucose uptake.

HiCrayon reveals distinct layers of multi-state 3D chromatin organization

HiCrayon co-visualizes 3D chromatin conformation with 1D genomic data to reveal new insights into chromatin organization.

Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample

This paper reports the 3D genome architecture of a 52,000-year-old woolly mammoth using a novel method, revealing conserved epigenetic features across elephantids.

Predicting A/B compartments from histone modifications using deep learning

This paper introduces a deep learning model to predict A/B compartments from histone modifications, achieving high accuracy across cell types and showing the importance of specific histone marks.

Fine-mapping of nuclear compartments using ultra-deep Hi-C shows that active promoter and enhancer elements localize in the active A compartment even when adjacent sequences do not

The paper uses ultra-deep Hi-C and a new computational method to fine-map nuclear compartments, revealing that active promoters and enhancers localize in the A compartment even when adjacent sequences are inactive.

Somatic chromosome pairing has a determinant impact on 3D 1 chromatin organization

The paper investigates how chromosome pairing affects 3D chromatin organization in Drosophila, showing it reinforces intrachromosomal interactions but not compartmental organization.

Sex-specific multi-level 3D genome dynamics in the mouse brain

This study examines 3D genome dynamics in mouse brain neurons across the estrous cycle and by sex, finding cycle-driven changes and estrogen-related similarities to male genomes.

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration

This study shows that pathological tau sequesters LSD1, leading to neurodegeneration, and that modulating LSD1 can mitigate tau-induced damage in a mouse model.

Immediate and deferred epigenomic signature of neuronal activation

The paper investigates transcriptional and chromatin changes in hippocampal neurons during and after activation, identifying immediate and long-term epigenomic signatures linked to neuroplasticity.