GeneticsbioRxivPreprint
Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease
Ryan D. Fine, Rebecca Chubaryov, Mingzhou Fu…·Aravinda Chakravarti
This study shows that reduced function alleles in Ret and Ednrb genes cause Hirschsprung disease by disrupting their gene regulatory network and leading to cell fate reversal in the enteric nervous system.
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