SOX9 acts as a dynamic pioneer factor inducing stable changes in the chromatin landscape to reprogram endothelial cells.
Bettina Maria Fuglerud, Sibyl Drissler, Jeremy Lotto, Tabea L. Stephan, Avinash Thakur, Rebecca L Cullum, Pamela A. Hoodless
The paper shows SOX9 acts as a pioneer factor that changes chromatin structure to drive endothelial-to-mesenchymal transition by activating mesenchymal enhancers and suppressing endothelial genes.
bioRxiv · Sep 11, 2020 · PreprintGenomics