GenomicsbioRxivPreprint
SOX9 acts as a dynamic pioneer factor inducing stable changes in the chromatin landscape to reprogram endothelial cells.
Bettina Maria Fuglerud, Sibyl Drissler, Jeremy Lotto…·Pamela A. Hoodless
The paper shows SOX9 acts as a pioneer factor that changes chromatin structure to drive endothelial-to-mesenchymal transition by activating mesenchymal enhancers and suppressing endothelial genes.