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2 papers
Recent·Most cited
Steven H Wu, Rachel S Schwartz, David J Winter, Don Conrad, Reed A Cartwright
The paper models whole genome sequencing read depth using mixtures of Dirichlet-multinomial distributions to improve genotyping accuracy and de novo mutation detection.
Bioinformatics · Mar 15, 2017Peer-reviewedGenomics
Hongan Long, David J Winter, Allan Y-C Chang, Way Sun, Steven H. Whu, Mariel Balboa, Ricardo BR Azevedo, Reed A Cartwright, Michael Lynch, Rebecca A Zufall
The paper measures the germline base-substitution mutation rate in Tetrahymena thermophila and finds it to be low, similar to Paramecium tetraurelia, but notes fitness decline in exclusion lines suggests other factors contribute to mutational load.
Genome Biology and Evolution · Sep 15, 2016Peer-reviewedEvolutionary Biology