SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase
Emma E. Drew, Hunter G. Nyvall, Matthew AH Parson, Reed K. Talus, John E. Burke, Scott D. Hansen
This study identifies how the SH2 domain sterically occludes the C2 domain to autoinhibit SHIP1, revealing structural and functional relationships critical for its membrane localization and phosphatase activity.
Journal of Biological Chemistry · Oct 7, 2025Peer-reviewedBiochemistry