Matthew AH Parson

This study develops domain-specific nanobodies that inhibit SARS-CoV-2 infection by disrupting N protein phase separation and replication.

This study identifies how the SH2 domain sterically occludes the C2 domain to autoinhibit SHIP1, revealing structural and functional relationships critical for its membrane localization and phosphatase activity.

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.

The paper reports a cryo-EM structure of Calcineurin bound to PI4KA, revealing direct interactions with both PI4KA and FAM126A and their conserved binding sequences.

This study identifies spartin as a lipid transfer protein essential for lipid droplet turnover via lipophagy, revealing a new lipid transport module in its senescence domain.