Neonatal NMDA receptor blockade disrupts prefrontal cortical regulation of social affective behavior: implications for schizophrenia
Reina Tachihara, Natsumi Hayashi, Carlos Gonzalez del Rosal, Tingbi Xiong, Keita Igarashi, Takaaki Ozawa, Miyo Hori, Kazuo Yamada, Michimasa Toyoshima
This study shows that neonatal NMDA receptor blockade impairs social affective behavior in rats, linked to reduced parvalbumin interneurons in the medial prefrontal cortex.
bioRxiv · Nov 6, 2026 · PreprintNeuroscience