Whole-genome profiling of native 5-hydroxymethylation in human neurons with long-read sequencing
Dennis Klose, Mohammad Hossein Sepehri, Remi-Andre Olsen, Ha T.H. Vu, Jason Ernst, Lara Kular, Maria Needhamsen, M Jagodic
The paper uses long-read sequencing to profile native 5hmC and 5mC in human neurons, showing 5hmC enrichment in transcribed regions and enhancers.
bioRxiv · Jan 12, 2026 · PreprintNeuroscience