Lara Kular

Advancing Neurological Liquid Biopsy via Six-Base Sequencing of Cerebrospinal Fluid Cell-Free DNA

This paper uses 6-base sequencing to analyze DNA modifications in cerebrospinal fluid cell-free DNA, providing insights into neurodegenerative biology for liquid biopsy applications.

Transgenic dCas9-DNMT3A mouse lines enable ex vivo and in vivo methylation editing with locus-dependent transcriptional effects

This study develops CRISPR-based mouse lines for locus-specific DNA methylation editing and shows locus-dependent transcriptional effects in vivo.

Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

Systematic comparison of dCas9-based DNA methylation epimodifiers over time indicates efficient on-target and widespread off-target effects

This study compares dCas9-based DNA methylation epimodifiers over time, showing efficient on-target effects but widespread off-target methylation and transcriptional changes.

Whole-genome profiling of native 5-hydroxymethylation in human neurons with long-read sequencing

The paper uses long-read sequencing to profile native 5hmC and 5mC in human neurons, showing 5hmC enrichment in transcribed regions and enhancers.

GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis

GeneSetCluster 2.0 improves gene-set analysis by reducing redundancies, enhancing computational efficiency, and providing accessible tools for both programmers and non-programmers.