Multidimensional dynamics of the proteome in the degenerative and ageing mammalian brain
Byron Andrews, Sarah Maslen, Leonardo Almeida-Souza, Mark J. Skehel, René Frank
This paper quantifies protein synthesis and degradation rates in mouse models of neurodegeneration and ageing using metabolic labeling and proteomics, revealing distinct dynamics in disease versus aging.
bioRxiv · Nov 17, 2018 · PreprintSystems Biology