Le­onardo Almeida-Souza

This study identifies Piezo1 as a regulator of focal and reticular adhesions, showing its role in EGFR clathrin-mediated endocytosis on stiff substrates.

This paper introduces IARA, a deep learning model that rapidly identifies optimal binding interfaces for protein binder design, reducing computational costs.

The paper shows that DDHD2-generated saturated fatty acids are essential for neuronal energy production and synaptic function.

EndoNB enables analysis of surface protein turnover at endogenous levels using CRISPR/Cas9 and a cleavable probe, demonstrating its utility in studying internalization dynamics.

This study identifies MICAL-L1's role in recruiting FCHSD2 to endosomes, which is essential for actin branching, fission, and receptor recycling.

This paper introduces an assay using free-floating liposomes to detect membrane curvature sensing and remodelling by proteins, revealing new insights into domain-specific preferences and activities.

This paper quantifies protein synthesis and degradation rates in mouse models of neurodegeneration and ageing using metabolic labeling and proteomics, revealing distinct dynamics in disease versus aging.