Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction
Renren Chen, Imogen Stockwell, Jessica C Pierce, Sew‐Yeu Peak‐Chew, Melissa Huang, Kathy L. Newell, Bernardino Francesco Ghetti, Michael Alan Cousin, Ingo H. Greger, Benjamin Falcon
This study shows TDP-43 filaments accumulate at synapses, causing presynaptic dysfunction and neuronal hyperexcitability in neurodegenerative diseases.
bioRxiv · Jan 27, 2026 · PreprintNeuroscience