Sew‐Yeu Peak‐Chew

The Pick fold in tau filaments from human MAPT mutants

This study reports cryo-EM structures of tau filaments from MAPT mutants, showing how specific mutations alter the Pick fold structure and enable reconstitution of variants.

Structural basis for GluA1 AMPA receptor regulation by PRRT1/SynDIG4 in LTP

This study identifies PRRT1/SynDIG4's role in regulating GluA1 AMPA receptors during LTP by sequestering the GluA1 C-terminus via a lipid modification, thereby affecting CaMKII access and LTP induction.

Dimerisation and twist reversal of the Lewy fold in α-synuclein mutants with Parkinson's disease and dementia

The paper reports the structures of α-synuclein filaments from individuals with Parkinson's disease and dementia, revealing differences in dimerisation and twist reversal between pathogenic and non-pathogenic variants.

Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction

This study shows TDP-43 filaments accumulate at synapses, causing presynaptic dysfunction and neuronal hyperexcitability in neurodegenerative diseases.

Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W

The paper determines the structures of tau filaments in individuals with MAPT mutations V337M and R406W using cryo-EM, finding the Alzheimer fold in all cases and a new triple filament assembly.

Mechanism of chaperone recruitment and retention on mitochondrial precursors

The paper shows that the mitochondrial targeting signal (MTS) regulates chaperone dynamics on mitochondrial precursors to buffer degradation and maintain import competence during stress.

Identification of Cellular Signatures Associated with Chinese Hamster Ovary (CHO) Cell Adaptation for Secretion of Antibodies

This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.

Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels

This paper identifies NACHO as an ER-resident protein that facilitates the assembly of pentameric ligand-gated ion channels by interacting with subunit interfaces.

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C

This study identifies heteromeric amyloid filaments composed of ANXA11 and TDP-43 in FTLD-TDP Type C using cryo-EM, revealing a new pathological mechanism.

Laminin 111 triggers cell quiescence and long-term survival by inducing IQGAP1-mediated cytosolic scaffolding of ERK and BAD inactivation

This paper identifies Laminin 111 as a trigger for cellular quiescence and long-term survival through IQGAP1-mediated cytosolic scaffolding of ERK and BAD inactivation.

Circadian clocks in human cerebral organoids

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy

The paper determines cryo-EM structures of Aβ40 filaments from Alzheimer's and cerebral amyloid angiopathy samples, revealing structural differences at higher resolution.

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation

The paper identifies how TTC5 recruits SCAPER to initiate tubulin mRNA degradation via interaction with the CCR4-NOT complex, linking ribosome-associated mRNA decay to microtubule regulation.

Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains

The paper reports cryo-EM structures of amyloid-beta filaments with the Arctic mutation from human and mouse brains, revealing structural differences and conformational changes.

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

The paper shows yeast cells use temporal metabolic oscillations to coordinate protein synthesis with energy availability, storing resources and releasing them in bursts to maintain homeostasis.

MALT1 mediates IL-17 Neural Signaling to regulate C. elegans behavior, immunity and longevity

The paper identifies MALT1 as a key mediator of IL-17 signaling in C. elegans neurons, showing its role in behavior, immunity, and longevity.