Ingo H. Greger

This study identifies PRRT1/SynDIG4's role in regulating GluA1 AMPA receptors during LTP by sequestering the GluA1 C-terminus via a lipid modification, thereby affecting CaMKII access and LTP induction.

The paper develops a diffusion-reaction model to analyze how vesicular acidification modulates AMPA receptor function and synaptic current.

This study shows TDP-43 filaments accumulate at synapses, causing presynaptic dysfunction and neuronal hyperexcitability in neurodegenerative diseases.

The paper shows that analyzing miniature postsynaptic currents (mPSCs) is unreliable for detecting synaptic changes due to incomplete detection and false confidence in results.

This study shows that disrupting the TARP-ARC interaction stabilizes synaptic AMPA receptors and rescues fear memory deficits caused by social isolation in mice.

This study shows dopamine increases protein synthesis in hippocampal neurons, enabling dopamine-dependent long-term potentiation through a distinct signaling pathway.

The paper investigates the modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics using cryo-EM structures, electrophysiology, and simulations, revealing ligand-dependent effects on receptor function.

The paper investigates how AMPA receptor anchoring at CA1 synapses is regulated by interactions between the N-terminal domain and TARP γ8, showing both are crucial for maintaining synaptic transmission.

This study determines cryo-EM structures of a heteromeric AMPA receptor complex in different states, revealing how auxiliary subunits modulate gating and synaptic function.

The paper develops an inhalation anaesthesia method for neonatal mice to enable streamlined stereotactic brain injections for transduction and modification of tissue.