GeneticsbioRxivPreprint
Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells
Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio…·Leif S. Ludwig
The paper uses single-cell multi-omics to study how pathogenic mtDNA mutations are subject to purifying selection in immune cells from Pearson syndrome patients.