Author

Christoph Muus

Broad InstituteORCID 0000-0003-2779-0893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Approach:machine learning (classical)· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Avinash WaghrayiD· 2 shared Ayshwarya SubramanianiD· 2 shared Daniel T. MontoroiD· 2 shared Evgenij FiškiniD· 2 shared Graham HeimbergiD· 2 shared Joshua GouldiD· 2 shared Karthik A. JagadeeshiD· 2 shared Leif S. LudwigiD· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Avinash WaghrayORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintNov 20, 2022

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells

Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio…·Leif S. Ludwig

The paper uses single-cell multi-omics to study how pathogenic mtDNA mutations are subject to purifying selection in immune cells from Pearson syndrome patients.

4 citations

humanscRNA-seq

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GenomicsbioRxivPreprintFeb 25, 2021

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Toni Marie Delorey, Carly G.K. Ziegler, Graham Heimberg…·Alexandra–Chloé Villani

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

40 citations

humanscRNA-seq

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BioinformaticsbioRxivPreprintApr 19, 2020

✦ In-depth digest

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Christoph Muus, Malte D. Luecken, Gökçen Eraslan…·Wenjun Yan

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.

236 citations

humanmouse

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