Profiling Lysosomal and Mitochondrial Dysfunction in Neurodegenerative Diseases Using Human Fibroblasts for Translational Therapeutic Screening
Diana M. Leite, Rhianna Lenham, Philippa Malko, Stuart Thomson, Tim Phillips, Tatiana Rosado Rosenstock, Naheed Rohman Mirza
The paper evaluates lysosomal and mitochondrial dysfunction in human fibroblasts from healthy donors and neurodegenerative disease patients, validating assays for high-throughput therapeutic screening.
bioRxiv · Jun 24, 2025 · PreprintNeuroscience