Author

Diana M. Leite

University College LondonORCID 0000-0002-6017-6433Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Giuseppe BattagliaiD· 2 shared Alessandro PomaiD· 1 shared Anđela ŠarićiD· 1 shared Aroa Duro‐CastañoiD· 1 shared Azzurra ApricenoiD· 1 shared Bin FangiD· 1 shared Diana MatiasiD· 1 shared Edoardo ScarpaiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Giuseppe BattagliaORCID

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Author profile →

3 papers

Recent·Most cited

Profiling Lysosomal and Mitochondrial Dysfunction in Neurodegenerative Diseases Using Human Fibroblasts for Translational Therapeutic Screening

Diana M. Leite, Rhianna Lenham, Philippa Malko, Stuart Thomson, Tim Phillips, Tatiana Rosado Rosenstock, Naheed Rohman Mirza

The paper evaluates lysosomal and mitochondrial dysfunction in human fibroblasts from healthy donors and neurodegenerative disease patients, validating assays for high-throughput therapeutic screening.

bioRxiv · Jun 24, 2025 · PreprintNeuroscience

On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias

Xiaohe Tian, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, Azzurra Apriceno, Alessandro Poma, Aroa Duro‐Castaño, Manish Reddy Vuyyuru, Lena Harker-Kirschneck, Anđela Šarić, Zhongping Zhang, Pan Xiang, , Giuseppe Battaglia

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.

Science Advances · Nov 27, 2020Peer-reviewedNeuroscience

The role of syndapin-2 mediated transcytosis across the blood-brain barrier on amyloid-beta accumulation in the brain

Diana M. Leite, Mohsen Seifi, Lorena Ruiz‐Pérez, Filomain Nguemo, Markus Plomann, Jerome D. Swinny, Giuseppe Battaglia

This study investigates how syndapin-2 mediated transcytosis affects amyloid-beta clearance across the blood-brain barrier and its implications for Alzheimer's disease and aging.

bioRxiv · Jul 12, 2020 · PreprintNeuroscience