Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation
Ellen Sapp, Adel Boudi, Andrew Iwanowicz, Jillian Belgrad, Rachael Miller, Riannon Robertson, Daniel O’Reilly, Ken Yamada, Yunping Deng, Marion Joni, Xueyi Li, Kimberly B. Kegel-Gleason, Anastasia Khvorova, Anton J. Reiner, Neil Aronin M. D, Marian DiFiglia
The paper detects HTT1a protein in Huntington's disease mouse brain using western blot with neo-epitope antibodies and shows that reducing MSH3 lowers HTT1a levels.
bioRxiv · Dec 31, 2024 · PreprintNeuroscience