Capabilities, specificity gaps and training-data dependence of AlphaFold3 across diverse application areas
Océane M. Follonier, Yan Liu, Pablo Campomanes, Luc Lafrenaye, Julien Racle, Daniel Alvarez, Julian van Gerwen, Ricardo Heinzmann, Jürgen Jänes, Eric Kummelstedt, Janani Durairaj, David Gfeller, Stefano Vanni, Pedro Beltrão
This paper evaluates AlphaFold3's performance across diverse structural biology tasks, finding uneven accuracy and strong dependence on training data.
bioRxiv · Jul 13, 2026 · PreprintBioinformatics