Daniel Álvarez

Capabilities, specificity gaps and training-data dependence of AlphaFold3 across diverse application areas

This paper evaluates AlphaFold3's performance across diverse structural biology tasks, finding uneven accuracy and strong dependence on training data.

The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins.

This study uses molecular dynamics simulations to reveal the mechanism of lipid transport by BLTPs, showing membrane destabilization is critical for lipid desorption.

Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1

The paper uses cryo-EM to study the VPS13A-XKR1 complex, revealing how it facilitates lipid transfer between membranes and how this process is enhanced by membrane properties.

TMEM170 family proteins are lipid scramblases that physically associate with bridge lipid transporters BLTP1/Csf1

The paper identifies TMEM170 family proteins as lipid scramblases that physically interact with BLTP1/Csf1, revealing a new mechanism for lipid transport between organelles.