Yan Liu

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

This study reports the structures of a mammalian gamma-CoV spike in closed and open conformations, revealing conserved mechanisms of spike dynamics and lipid binding's role in stabilizing the closed state.

This study examines mutations in H5N1 influenza virus HA that affect receptor binding and antiviral susceptibility, finding reduced sialic acid binding correlates with mucus evasion and antiviral resistance.

This paper evaluates AlphaFold3's performance across diverse structural biology tasks, finding uneven accuracy and strong dependence on training data.

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

This study shows that unpaired TCRα + TCRβ sequencing can train accurate TCR-epitope recognition predictors at lower cost than paired sequencing.

This study shows that secreted M protein, not cell-surface M protein, is critical for lymphatic survival and systemic infection of Streptococcus pyogenes in mice.

The paper introduces TCR specificity profiles to identify key determinants of TCR-epitope recognition and shows their ability to predict cross-reactivity and interpret machine learning models.

This paper develops and tests CAR-NK-92 cells targeting Candida albicans mannan, showing enhanced antifungal activity and reduced fungal burden in mice.

This study uses scRNA-seq to analyze PBMCs in KD patients and healthy controls, identifying altered B cell subsets and reduced NK cell cytotoxicity.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

This study analyzes 440 Hmong-Mien genomes to reveal genetic differentiation, admixture, and migration patterns, supporting isolation and long-distance migration.

The paper reports two cases of Delta/Omicron and two cases of Omicron/BA.2 co-infections in immunocompromised hosts detected by genotyping and confirmed by whole genome sequencing.

This paper analyzes genomic data from Sherpa people to explore their genetic origin, evolutionary history, and forensic characteristics using InDels and SNPs.

The paper predicts bacterial carbohydrate-binding proteins (lectins) across genomes to explore their role in vaginal microbiome colonization and pathogenicity.