Jürgen Jänes

The paper identifies phosphorylation sites that regulate protein interactions using pan-cancer data and AlphaFold predictions, revealing 6,160 associations between phosphosites and interacting protein abundance.

This paper evaluates AlphaFold3's performance across diverse structural biology tasks, finding uneven accuracy and strong dependence on training data.

The paper develops predictors to functionally characterize human phosphosites using integrated data, revealing novel functions and connections to DNA repair and cell survival.

The paper predicts protein-protein interactions in Mycoplasma genitalium using a pooled-AlphaFold3 approach, improving accuracy and efficiency over traditional methods.

The paper uses AlphaFold to predict structures of host-pathogen PPIs, revealing molecular mimicry modes and convergent evolution of interaction interfaces.

The paper predicts the mechanistic impacts of human protein missense variants on stability, protein-protein interactions, and small-molecule binding using AlphaFold2 structures.

A Foldseek-based linear-time structural clustering groups 52 million AlphaFold DB representatives into 2.27 million non-singleton clusters; 31% lack known structural or domain annotation.

The paper identifies distinct regulatory architectures for ubiquitous, germline, and somatic genes in C. elegans by analyzing promoter features across five tissues.

The paper maps regulatory elements across C. elegans development and ageing, identifying promoters and enhancers and showing their dynamic accessibility linked to developmental processes.