Conformational dynamics at the pre-miR-377 Dicer site governs selective small-molecule recognition
Jacopo Manigrasso, Emeline Mestdach, Ricardo quaia, Daniela Danková, Mattias Bood, Malin Lemurell, Stefan Geschwindner, Andrey I. Frolov, Matthew David Disney, Anders Hogner, N. Celestine, Giuseppina La Sala
The paper studies how dynamic conformational changes in pre-miR-377's Dicer site enable small-molecule recognition, showing that binding depends on RNA dynamics rather than a single structure.
bioRxiv · Feb 12, 2026 · PreprintBiophysics