Stefan Geschwindner

Discovery of Membrane Channel Modulators via DNA-Encoded Library Screening Using Native-Like Membrane Protein Nanoparticles

This paper develops a method to discover PANX1 modulators using DNA-encoded library screening with stabilized membrane protein nanoparticles and validates hits through biophysical and electrophysiological assays.

Conformational dynamics at the pre-miR-377 Dicer site governs selective small-molecule recognition

The paper studies how dynamic conformational changes in pre-miR-377's Dicer site enable small-molecule recognition, showing that binding depends on RNA dynamics rather than a single structure.

Unveiling the Power of PROTAC Valency: Navigating Cell Type-Specific Hook Effects

The paper evaluates the impact of PROTAC valency on hook effects, showing that trivalent PROTACs do not eliminate the hook effect but may alter its dynamics.

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.