The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal
Paola Cattaneo, Michael G.B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip Servet Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory J. Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, , Sylvia Μ. Evans
This study shows that DOT1L regulates specific gene networks in cardiac development and cell cycle withdrawal through H3K79me2 modifications.
Nature Communications · Dec 2, 2022Peer-reviewedDevelopmental Biology