Sylvia Μ. Evans

Transcriptional Readthrough at Atf4 Locus Suppresses Rps19bp1 and Impairs Heart Development

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

Adventitial leptin receptor-expressing fibroblasts are preferential contributors to fibrotic remodeling of the heart post infarction

This study identifies adventitial leptin receptor-expressing fibroblasts as key contributors to cardiac fibrosis after myocardial infarction in mice and humans.

The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal

This study shows that DOT1L regulates specific gene networks in cardiac development and cell cycle withdrawal through H3K79me2 modifications.

Unveiling unexpected complexity and multipotentiality of early heart fields

The paper reveals unexpected complexity and multipotentiality of early heart fields through lineage and single-cell analyses, identifying new progenitor sources and developmental relationships.

IL-11 is a therapeutic target in idiopathic pulmonary fibrosis

The paper identifies IL-11 as a therapeutic target in idiopathic pulmonary fibrosis by showing its role in fibroblast activation and fibrosis progression across species.

3D Chromatin Architecture Remodeling during Human Cardiomyocyte Differentiation Reveals A Role Of HERV-H In Demarcating Chromatin Domains

The paper investigates chromatin architecture changes during human cardiomyocyte differentiation and identifies HERV-H retrotransposons as key regulators of TAD boundaries and gene regulation.

Assembly of functionally antagonistic visual circuits for controlling pupil dynamics

The paper identifies a novel genetic program and circuit involving Tbx20-expressing retinal ganglion cells that control pupil dynamics through specific neural pathways.

Repression of Dlx1/2 Signaling by Nolz-1/Znf503 is Essential for Parcellation of the Striatal Complex into Dorsal and Ventral Striatum

The paper shows that Nolz-1 suppresses Dlx1/2 to control striatal subdivision into dorsal and ventral regions during development.

A human cell model of cardiac pathophysiological valvulogenesis

This paper develops a human pluripotent stem cell model to study valvulogenesis and disease, showing it can recapitulate valve development and disease traits like mitral valve prolapse.