Ju Chen

This study shows that Perm1 in cardiomyocytes is essential for maintaining cardiac bioenergetic reserve, affecting exercise capacity but not resting function.

The paper identifies MARPs as key modulators of titin-based mechanotransduction and shows mTORC1 regulates longitudinal muscle hypertrophy in response to stretch.

This study shows lipoxins modulate immune responses and cardiac signaling in male MLPko mice with dilated cardiomyopathy, but not in females.

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

This study shows RBPMS and RBPMS2 work together to regulate cardiac splicing, with double knockout mice dying in utero due to sarcomere disarray, while single knockouts survive with normal sarcomere structure.

This study shows that DOT1L regulates specific gene networks in cardiac development and cell cycle withdrawal through H3K79me2 modifications.