Snapshots of Pseudomonas aeruginosa SOS response activation complex reveal structural prerequisites for LexA engagement and cleavage
Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron
This study reveals the structural basis of RecA-LexA interaction in Pseudomonas aeruginosa, showing how RecA triggers LexA cleavage and inactivation, which is critical for the SOS response.
iScience · Jan 2, 2025Peer-reviewedBiochemistry