Arjen J. Jakobi

This study validates engineered hyper-stable human serum albumin variants for their structural integrity and functional adaptability in biotechnological applications.

This study develops nanobodies to selectively probe different states of GBP coat assembly and function in human cells.

This paper introduces LocScale-2.0 and LocScale-FEM to improve cryo-EM map quality by enhancing local detail while preserving weak structural context and providing confidence scores for interpretation.

The paper introduces SURFER, a tool for segmenting membrane and membrane mimic densities in cryo-EM maps to improve analysis and visualization.

The paper presents three strategies for live feedback control during the fabrication of frozen-hydrated lamellae using cryogenic FIB-SEM, ensuring thickness and quality.

This study reveals the structural basis of RecA-LexA interaction in Pseudomonas aeruginosa, showing how RecA triggers LexA cleavage and inactivation, which is critical for the SOS response.

The paper introduces Roodmus, a toolkit for benchmarking heterogeneous cryo-EM reconstructions using synthetic data with known ground truth.

This paper introduces a new cryogenic microscope that combines fluorescence, ion beam, and electron beam imaging to improve the targeting and fabrication of lamellae for high-resolution imaging.

This study determines the structural basis of p62/SQSTM1 PB1 domain filaments, their role in phase-separated p62 bodies, and their importance in cargo recognition and lysosomal targeting.