The effects of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain.
Daniel E. Radford‐Smith, Catriona H. E. Rooney, Jordan McGing, Ayaka Shinozaki, Surrin S. Deen, Fulvio Zaccagna, Richard Healicon, Vicky Ball, Daniel C. Anthony, Damian J. Tyler, James T. Grist
This study investigates how elevated serum lactate affects cerebral perfusion and metabolism in anesthetized rodents using hyperpolarized 13C MRI, finding significant changes in perfusion and lactate:pyruvate ratios but not bicarbonate:pyruvate ratios.
bioRxiv · Dec 20, 2025 · PreprintNeuroscience