Damian J. Tyler

Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation

This study uses multimodal metabolic analysis to detect early metabolic changes in acute neuroinflammation, showing reduced pyruvate metabolism and ongoing inflammation without structural MRI changes.

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

The effects of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain.

This study investigates how elevated serum lactate affects cerebral perfusion and metabolism in anesthetized rodents using hyperpolarized 13C MRI, finding significant changes in perfusion and lactate:pyruvate ratios but not bicarbonate:pyruvate ratios.

Modulating Cardiac Energetics in Cardio-Metabolic Syndromes: A mechanistic, hyperpolarized MR Trial of Ninerafaxstat Treatment

This paper evaluates the effects of ninerafaxstat on cardiac energetics and function in patients with cardio-metabolic syndromes using hyperpolarized MR and metabolomics.