A missense variant effect map for the human tumour suppressor protein CHK2
Marinella Gebbia, Daniel Zimmerman, Rosanna Jiang, Maria Nguyen, Jochen Weile, Roujia Li, Michelle Gavac, Nishka Kishore, Song Sun, Rick A.C.M. Boonen, Jennifer N. Dines, Alexander Wahl, Jason Reuter, Britt A. Johnson, Douglas M. Fowler, , Frederick P. Roth
The paper creates a functional map of all possible missense variants in CHK2 to assess their impact on cancer risk.
bioRxiv · Feb 13, 2024 · PreprintGenetics