Author
Leiden University Medical CenterORCID 0000-0001-8590-0240Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Sjoerd J. Klaasen, Kruno Vukušić, Michael M.R. van Gerven…·Martijn S. Luijsterburg
This study identifies resistance mechanisms and vulnerabilities to KIF18A inhibition in cancer cells using CRISPR screening and drug adaptation.
Jolanthe Lingeman, Diana van den Heuvel, Jeroen van den Berg…·Haico van Attikum
This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother…·Haico van Attikum
This study identifies FANCL and Ube2T as HR-promoting factors at DSBs and shows they regulate CtIP recruitment and end-resection for homologous recombination.
Marinella Gebbia, Daniel Zimmerman, Rosanna Jiang…·Frederick P. Roth
The paper creates a functional map of all possible missense variants in CHK2 to assess their impact on cancer risk.
Bert van de Kooij, A. Schreuder, Raphael Pavani…·Sylvie M. Noordermeer
This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.
Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe
The paper introduces DSB-Spectrum reporters to analyze DNA repair pathway cross-talk and shows that DNA-PKcs inhibition increases SSA and HR, while end-resection factors influence pathway competition.
Ignacio Alonso‐de Vega, Maria Cristina Paz‐Cabrera, Magdalena B. Rother…·Veronique A. J. Smits