Cell BiologybioRxivPreprint
Chaperone-mediated autophagy is an overlooked pathway for mutant alpha-1 antitrypsin Z degradation
Jiayu Lin, Haorui Lu, Xinyue Wei…·Lang Rao
This study identifies chaperone-mediated autophagy (CMA) as a key pathway for degrading mutant alpha-1 antitrypsin Z (ATZ), showing that enhancing CMA reduces ATZ accumulation in AATD.
DOI 10.1101/2023.11.24.568525