Megalin deficiency perturbs retinal homeostasis and impairs cathepsin D processing and phagosome-lysosome maturation in the retinal pigment epithelium
Ditte K. Rasmussen, Pernille Lajer Marschall, Lee Soo Hyeon, Tina Storm, Thomas Stax Jakobsen, Qi Wu, Anne Louise Askou, Robert A. Fenton, Thomas Corydon, Vinit B. Mahajan, Rikke Nielsen
This study shows megalin deficiency disrupts retinal homeostasis by impairing phagosome-lysosome maturation and cathepsin D processing in the RPE.
bioRxiv · Jun 26, 2026 · PreprintCell Biology