Qi Wu

This study uses deep learning to analyze proteomic data from mouse kidney compartments, revealing distinct injury programs in proximal tubules and glomeruli in diabetic kidney disease.

This study shows megalin deficiency disrupts retinal homeostasis by impairing phagosome-lysosome maturation and cathepsin D processing in the RPE.

This study develops a mammalian cell model to investigate NKCC2 ubiquitylation, showing that K871 ubiquitylation regulates membrane localization and function, while Nedd4-2 affects total abundance but not trafficking.

This study shows that the xCT transporter regulates cGAS-dependent interferon responses to DNA and HSV-1 by controlling glutamate levels and cGAMP production.

This study shows that kidney kallikrein-1 contributes to gamma-ENaC cleavage but is not essential for overall ENaC function or electrolyte balance.

This paper uses single-cell proteomics by mass spectrometry (SCP-MS) to analyze mouse kidney cells, revealing previously undetected protein-level heterogeneity, including a proliferative subset of distal convoluted tubule cells.