Megalin deficiency perturbs retinal homeostasis and impairs cathepsin D processing and phagosome-lysosome maturation in the retinal pigment epithelium
Ditte K. Rasmussen, Pernille Lajer Marschall, Lee Soo Hyeon…·Rikke Nielsen
This study shows megalin deficiency disrupts retinal homeostasis by impairing phagosome-lysosome maturation and cathepsin D processing in the RPE.