Age-dependent accumulation of RAD51 on non-damaged chromosomes prevents chromosome segregation in mammalian oocytes
Masaru Ito, Shou Soeda, Tomo Kondo, Asako Furukohri, みどり 梶谷, Rina Ogata, Miho Ohsugi, Akira Shinohara
This study shows that RAD51 accumulates on non-damaged chromosomes in aging oocytes, leading to chromosome segregation failure and meiosis I arrest.
bioRxiv · Mar 20, 2026 · PreprintCell Biology